ADVANCED WOUND MANAGEMENT
Infection management
As a route to more effective infection management,1 use our clear, concise treatment pathway, which may help improve patient outcomes through accurate decision-making, a fast response and effective treatment choices1
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Transforming outcomes, changing lives
Chronic wounds such as diabetic foot ulcers, venous leg ulcers and pressure ulcers can be costly and hard to treat
The presence of infection and biofilm can delay healing, cause wider complications - such as amputation or systemic infection - and increase costs2-5
Treating an infected VLU with an antimicrobial in the UK can cost on average £10,7776
Our new infection management pathway aims to help reduce the risk of spreading and systemic infection, to help improve outcomes and reduce costs.1
The right antimicrobial solution at the right time
Expert consensus recommendations tell us that chronic wounds with local or spreading infection need to be managed differently to wounds with biofilm associated infection.3
Local and spreading infection
Act fast on local infection with ACTICOAT◊ Dressings to help reduce the risk of progression to systemic infection.7-9
Signs and symptoms of biofilm
IODOSORB◊ Cadexomer Iodine products can disrupt and kill biofilm – helping remove barriers to healing.10-17
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Citations
1. Dowsett, C., Bellingeri, A., Carville, K., Garten, A. & Woo, K. A route to more effective infection and biofilm management. Wounds Int. ahead of p, (2020).
2. Guest, J. et al Costs and consequences of managing infection associated with venous leg ulcers in the UK. Presented at: CATALYST Health Economics Consultants Ltd; UK. 2017.
3. Schultz, G. et al. Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds. Wound Repair Regen. 25, 744–757 (2017). 5
4. Malone, M. et al. The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. J. Wound Care 26, 20–25 (2017).
5. Guest, J. F., Fuller, G. W. & Vowden, P. Diabetic foot ulcer management in clinical practice in the UK: costs and outcomes. Int. Wound J. 15, 43–52 (2018).
6. Guest, J. F., Fuller, G. W. & Vowden, P. Venous leg ulcer management in clinical practice in the UK: costs and outcomes. Int. Wound J. 15, 29–37 (2018).
7. Cuttle L, Naidu S, Mill J, et al. A retrospective cohort study of Acticoat versus Silvazine in a paediatric population. Burns. 2007;33(6):701 - 707.
8. Smith+Nephew 2020.ACTICOAT Classic (ACTICOAT 3) PMCF Activity Summary Report. Internal Report. EO.AWM.PCS105.001.v2.
9. Smith+Nephew 2020.ACTICOAT 7 PMCF Activity Summary Report. Internal Report. EO.AWM.PCS105.002.v2.
10. Fitzgerald DJ, Renick PJ, Forrest EC, et al. Cadexomer iodine provides superior efficacy against bacterial wound biofilms in vitro and in vivo. Wound Repair Regen. 2017;25(1):13-24.
11. Akiyama H, Oono T, Saito M, Iwatsuki K. Assessment of Cadexomer Iodine against Staphylococcus aureus Biofilm In vivo and In vitro Using Confocal Laset Scanning Microscopy. The Journal of Dermatology. 2004;31:529-534.
12. Phillips PL, Yang Q, Davis S, et al. Antimicrobial dressing efficacy against mature Pseudomonas aeruginosa biofilm on porcine skin explants. Int Wound J. 2015;12(4):469-483.
13. Forrest EC, Gunning P, Coleman D, Fitzgerald DJ. Cadexomer Iodine delivers rapid and sustained broad spectrum antimicrobial activity and substantial biofilm disruption and kill in a clinically relevant wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden.
14. Smith & Nephew 2008.IODOFLEX dressings - disruption of a variety of micro-organisms grown in pre-established single and mixed species biofilms. Internal Report. 0804007.
15. Roche ED, Woodmansey EJ, Yang Q, et al. Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo. Int Wound J. 2019;1-10 [in press].
16. Schultz G, Qingpin Y. Microbicidal Effedts of Three Daily Treatments of a Carboxymethylcellulose Silver Dressing or a Cadexomer Iodine on Mature Bactericidal Biofilms Grown on Pig Skin Explants. 2016; Florence.
17. Oates JL, Phillips CD, Wolcott R, Woodmansey E. Effect of a Cadexomer Iodine Wound Dressing on a Chronic Wound Multi-Species Biofilm Model with Comparison to a Silver Hydrofiber Antibiofilm Dressing. Paper presented at: SAWC; 2016; Las Vegas, USA.
18. Hesler B. Release of iodine from IODOSORB/IODOFLEX Dressing into 0.9% saline solution over a three day period. Smith&Nephew Data on File # DS.18.026.R. (2018).
19. Hesler B. Release of iodine from IODOSORB Powder into 0.9% saline solution over a three day period. Smith&Nephew Data on File # DS.18.024.R. (2018).
20. Hesler B. Release of iodine from IODOSORB Ointment into 0.9% saline solution over a three day period. Smith&Nephew Data on File # DS.18.025.R. (2018).
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