SPORTS MEDICINE
REGENETEN◊ Bioinductive Implant
Supports rotator cuff tendon-like tissue growth, 1,2,4,5 and shown to reduce the risk and incidence of re-tears following full-thickness tear repairs12
Redefining biological healing
Supports the body’s own healing response to facilitate new tendon-like tissue growth and changes the course of rotator cuff disease progression.2-6
Comprised of type 1 collagen,7 it's an advanced healing solution for biological tendon regeneration for the entire spectrum of disease, from partial-thickness to massive rotator cuff tears.1-6,8
Product Features
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Clinical Evidence
Smith+Nephew is proud of its established body of evidence, including Level 1 RCT direct head-to-head comparison of standard of care rotator cuff repair +/- REGENETEN.
Medical Education
Disclaimer
*Finite element analysis indicated that the addition of 2 mm of tendinous tissue on the bursal side of a supraspinatus tendon with an articular-sided tear reduced the peak strain at the site of the tear by 40%.
**On human biopsy (n=1) and in-vivo sampling.
***Patients with partial thickness tears; 3 to 12 months n=46, 2 year n=13, 5 years n=11.
****Demonstrated in a study of patients with partial-thickness tears.
*****Demonstrated in patients with partial and full-thickness tears, compared to pre-operative values; p≤0.015.
Citations
- Thon SG, et al. Am J Sports Med. 2019;47(8):1901-1908.
- Van Kampen C, et al. Muscles Ligaments Tendons J. 2013;3(3):229-235.
- Bokor DJ, et al. MLTJ. 2019;9(3):338-347.
- Schlegel TF, et al. J Shoulder Elbow Surg 2017;27(2):242-251.
- Bokor DJ, et al. Muscles, Ligaments Tendons J 2016;6(1):16-25.
- McElvany MD, et al. Am J Sports Med. 2015;43(2):491-500.
- Smith+Nephew 2020. Internal report. REGENETEN Collagen Implant Physical Characteristics.
- McIntyre LF, et al. Arthroscopy. 2019 July 23.
- Material and Structural Testing Core, Mayo Clinic 2019. Internal report. EO/SPM/REGENTEN/001/V1.
- Arnoczky SP, et al. Arthroscopy. 2017;33(2):278-283.
- Schlegel TF, et al. JSES. 2021;30(8):1938-48.
- Ruiz-Ibán MA, et al. Arthroscopy. Published online December 27, 2023.